Excess secretion of growth hormone in children produces the syndrome known as Gigantism. The excessive growth hormone causes a massive acceleration of growth, and heights in excess of 7-8 feet can be reached.
In the adult, excess growth hormone presents as Acromegaly. Acromegaly can present in a huge array of signs and symptoms. A list of the signs and symptoms of acromegaly is given below:
The most common presenting complaint is that of a change in appearance. This is can be seen by studying old photographs. Acromegaly usually presents as a subtle disease with the clinical features developing over many years.
Some patients may present with galactorrhoea as in some tumours, both somatotrophin and prolactin are secreted.
Approximately a quarter of acromegaly patients have an impaired glucose tolerance due to the increased gluconeogenesis produced by the growth hormone.