This is an autoimmune condition characterised by:
Polyneuropathy - dysfunctioning peripheral motor and sensory nerves
Organomegaly - enlargement of organs such as the liver and spleen
Endocrinopathy - dysfunctioning endocrine glands producing adrenal insufficiency, hypothyroidism and type II diabetes mellitus due to pancreatic damage
M proteins - antibody proteins produced by plasmacytomas (tumours in the bone marrow) that target the nerves producing the polyneuropathy
Skin changes - changes such as hyperpigmentation and excessive hair growth can occur
Radiotherapy and chemotherapy are used to eliminate the plasmacytomas that are producing the M protein causing the neurological signs. Hormone replacement therapy can be used to replace missing hormones from malfunctioning endocrine glands.