What is the Treatment of Gonadotrophinomas & TSHomas?

The treatment of choice for gonadotrophinomas is trans-sphenoidal surgery followed by radiotherapy. The surgery improves the vision and will reduce the FSH levels. The radiotherapy has then been shown to further reduce the FSH levels. Medical treatment such as bromocriptine or gonadotrophin-releasing hormone (GnRH) analogues can be tried but are rarely successful.

The treatment of choice for TSHomas is again that of surgery followed by radiotherapy if required. In the short term these tumours can be controlled using octreotide (a somatostatin analogue).

Details of the surgery can be found in detail in the surgery section.